Matching wits with melanoma brain metastases: from biology to therapeutics.
Identifieur interne : 002256 ( Main/Exploration ); précédent : 002255; suivant : 002257Matching wits with melanoma brain metastases: from biology to therapeutics.
Auteurs : Hussein Tawbi [États-Unis]Source :
- Clinical cancer research : an official journal of the American Association for Cancer Research [ 1078-0432 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Mélanome, Tumeurs du cerveau.
- génétique : Mélanome, Métastase tumorale, Phosphatidylinositol 3-kinases, Tumeurs du cerveau.
- Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Phosphatidylinositol 3-Kinases.
- genetics : Brain Neoplasms, Melanoma, Neoplasm Metastasis.
- pathology : Brain Neoplasms, Melanoma.
- Humans.
Abstract
Melanoma brain metastases (MBM) present a significant clinical challenge. Molecular profiling of MBM is useful to identify molecular pathways, such as the PI3K pathway, that are specifically and differentially altered in MBM. Therapeutic studies should recruit patients with MBM and prospective tissue collection will lay the foundation for further advances.
DOI: 10.1158/1078-0432.CCR-14-1121
PubMed: 25135484
Affiliations:
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Le document en format XML
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University of Pittsburgh Cancer Institute Melanoma and Skin Cancer Program, Pittsburgh, Pennsylvania. tawbih@upmc.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. University of Pittsburgh Cancer Institute Melanoma and Skin Cancer Program, Pittsburgh</wicri:cityArea></affiliation></author></analytic><series><title level="j">Clinical cancer research : an official journal of the American Association for Cancer Research</title><idno type="ISSN">1078-0432</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain Neoplasms (genetics)</term><term>Brain Neoplasms (pathology)</term><term>Humans</term><term>Melanoma (genetics)</term><term>Melanoma (pathology)</term><term>Neoplasm Metastasis (genetics)</term><term>Phosphatidylinositol 3-Kinases (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Mélanome (anatomopathologie)</term><term>Mélanome (génétique)</term><term>Métastase tumorale (génétique)</term><term>Phosphatidylinositol 3-kinases (génétique)</term><term>Tumeurs du cerveau (anatomopathologie)</term><term>Tumeurs du cerveau (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Phosphatidylinositol 3-Kinases</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mélanome</term><term>Tumeurs du cerveau</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Brain Neoplasms</term><term>Melanoma</term><term>Neoplasm Metastasis</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Mélanome</term><term>Métastase tumorale</term><term>Phosphatidylinositol 3-kinases</term><term>Tumeurs du cerveau</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain Neoplasms</term><term>Melanoma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Melanoma brain metastases (MBM) present a significant clinical challenge. Molecular profiling of MBM is useful to identify molecular pathways, such as the PI3K pathway, that are specifically and differentially altered in MBM. Therapeutic studies should recruit patients with MBM and prospective tissue collection will lay the foundation for further advances.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Tawbi, Hussein" sort="Tawbi, Hussein" uniqKey="Tawbi H" first="Hussein" last="Tawbi">Hussein Tawbi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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